Cell Adhesion in Cancer

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Cell Adhesion in Cancer

1Department of Life Sciences, Division of Life and Pharmaceutical Sciences and the Center for Cell Signaling & Drug Discovery Research, Ewha Womans University, Seoul 120-750, Republic of Korea 2Division of Cancer Cell Research, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan 3Department of Gynecology and Obstetrics, Medical Center, University of Münster, D-48...

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Introduction Cadherin cell-adhesion molecules and their intracellular binding partners, catenins, were discovered in the 1980s (for a review, see Takeichi, 1995). Interest in these molecules was sparked by the discovery that cadherins and, subsequently, catenins are important in the formation and metastasis of carcinomas (Behrens et al, 1989; Berx et al, 1998; Perl et al, 1998; Polakis, 2000). ...

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Filopodia and adhesion in cancer cell motility.

Slender bundled actin containing plasma membrane protrusions, called filopodia, are important for many essential cellular processes like cell adhesion, migration, angiogenesis and the formation of cell-cell contacts. In migrating cells, filopodia are the pioneers at the leading edge which probe the environment for cues. Integrins are cell surface adhesion receptors critically implicated in cell...

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Rab11 is required for maintenance of cell shape via βPS integrin mediated cell adhesion in Drosophila

In eukaryotes, vesicle trafficking is regulated by the small monomeric GTPases of the Rab protein family. Rab11, (a subfamily of the Ypt/Rab gene family) an evolutionarily conserved, ubiquitously expressed subfamily of small monomeric Rab GTPases, has been implicated in regulating vesicular trafficking through the recycling of endosomal compartment. In an earlier communication, we have shown th...

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Objective(s): The present paper aims to review the studies describing the interactions between HopQ and CEACAMs along with possible mechanisms responsible for pathogenicity of Helicobacter pylori.Materials and Methods: The literature was searched on “PubMed” using different key words including Helicobacter pylori, CEACAM and gastric.<br ...

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ژورنال

عنوان ژورنال: International Journal of Cell Biology

سال: 2012

ISSN: 1687-8876,1687-8884

DOI: 10.1155/2012/965618